PRODUCT INFORMATION

DESCRIPTION
Gonazon for Fish contains a potent analogue of gonadotrophin-releasing hormone (GnRH/LHRH), azagly-nafarelin, at 1,600 µg/ml concentrate, and a diluent for dilution prior to injection.

INDICATIONS
Induction and synchronization of ovulation for the production of eyed-eggs and fry.

DOSAGE
Inject intraperitoneally along the central line, ½ to 1 fin length in front of the pelvic fin base. Fish should be anaesthetised.
The recommended clinical dose is 32 µg/kg body weight corresponding to 1 ml concentrate/50 kg of fish. This dose should be administered in the preferred volume for the particular body weight of fish. The supplied diluent is used to dilute the concentrate to the correct dilution to allow for optimisation of the preferred injection volumes for fish of widely varying body weights.
The table below provides the required volume of concentrate and the required volume of diluent to obtain the preferred injection volumes of 0.1 ml/kg fish, 0.2 ml/kg fish, 0.5 ml/kg fish or 1 ml/kg fish.

TABLE>>>>
Preferred injection volume per kg fish (depending on fish size)*
0.1 ml 0.2 ml 0.5 ml 1.0 ml
Total kg of fish to be injected Concentrate volume Diluent volume
50 kg 1 ml 4 ml 9 ml 24 ml 49 ml
100 kg 2 ml 8 ml 18 ml 48 ml 98 ml

*This volume will be minimized for the species with the largest body weights.

WITHHOLDING PERIOD
Zero days.

PRESENTATION
Carton: 1 concentrate vial and 1 bottle of diluent.
Concentrate vial: 3 ml brown glass vial containing 2 ml of concentrate solution.
Diluent bottle: 100 ml clear glass bottle containing 100 ml of diluent solution.
The empty, sterile vial (50 ml) is intended to be used for mixing the concentrate and solvent. Additional sterile vials will be supplied on request.

STORAGE
Store at 2 - 8°C (in a refrigerator). Do not freeze. Do not use after the expiry date stated on the label. After first opening the container, the diluent may be stored for 28 days. After dilution, the product should be used immediately.

CONTRA-INDICATIONS
Do not use Gonazon before approximately 10% of the specific brood stock population has ovulated naturally.
The product should not be used in fish maintained in water temperatures that would normally inhibit ovulation as this can result in a decrease in egg quality.

FURTHER INFORMATION
It is recommended to strip fish after injection at intervals of approximately 50-100 degree days. For Arctic charr, injections should be given only if the water temperature is < 8°C. The long-term effects of azagly-nafarelin on treated broodstock fish have not been studied.

UNDESIRABLE EFFECTS
Reductions in fecundity, egg quality and survival to the eyed-egg stage have been observed in fish treated with azagly-nafarelin too early in the season. In some cases, this can be related to the use of the compound too early in the spawning season.

PRECAUTIONS/WARNING
High standards of biosecurity must be observed at the time of injection in order to prevent the spread of infectious diseases between broodstock fish. Avoid self injection. In the case of accidental self-injection seek medical advice immediately and show the package insert or the label to the physician. Operators should wash their hands after use of the product.